Promethazine Signals and indications of overdosage with promethazine range from mild despair of the central anxious technique and cardiovascular technique to profound hypotension, respiratory depression, unconsciousness and unexpected Demise.
In One more review just one a hundred-mg/kg dose of codeine administered to pregnant mice reportedly resulted in delayed ossification in the offspring.
A probably deadly symptom advanced sometimes generally known as Neuroleptic Malignant Syndrome (NMS) has actually been documented in association with promethazine HCl by yourself or in combination with antipsychotic medicines.
Impaired secretion from sweat glands subsequent poisonous doses of medications with anticholinergic Uncomfortable side effects may possibly predispose to hyperthermia.
The respiratory-depressant outcomes of narcotic analgesics and their potential to elevate cerebrospinal fluid strain could possibly be markedly exaggerated inside the presence of head damage, intracranial lesions or even a pre-existing rise in intracranial force.
The diagnostic analysis of clients using this type of syndrome is challenging. In arriving in a analysis, it's important to determine situations exactly where the scientific presentation includes the two severe health-related illness (e.
The causal function of opioids during the scientific syndrome of hypogonadism is unknown since the several health-related, Bodily, lifestyle, and psychological stressors which could impact gonadal hormone levels haven't been sufficiently managed for in experiments done to this point [see Adverse Reactions (6)].
If the reaction to an opioid antagonist is suboptimal or only temporary in mother nature, administer added antagonist as directed through the merchandise’s prescribing info. The respiratory depressant effects of promethazine are usually not reversed by opioid antagonists, such as naloxone.
Disorders OF USE: The knowledge With this database is meant to nutritional supplement, not substitute for, the knowledge and judgment of Promethazine codeine syrup Health care professionals. The information will not be meant to protect all doable uses, directions, safety measures, drug interactions or adverse results, nor ought to it's construed to point that utilization of a particular drug is Secure, correct or effective for you or any person else.
Animal reproduction research haven't been done While using the drug blend-promethazine and codeine. It's not at all identified no matter whether this drug blend could cause fetal damage when administered to your Expecting lady or can affect replica capability.
Make use of other supportive steps (such as oxygen and vasopressors) during the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require Innovative life-help techniques. Gastric emptying could be helpful in getting rid of unabsorbed drug.
Daily life-threatening respiratory melancholy and death have happened in little ones who been given codeine. A lot of the reported cases occurred next tonsillectomy and/or adenoidectomy, and several of the kids had proof of remaining an extremely-rapid metabolizer of codeine on account of a CYP2D6 polymorphism [see Warnings and Precautions (5.
Caution really should be exercised when promethazine with codeine syrup is administered into a nursing lady.
If you don't have a drug get-again spot near you, flush any unused narcotic drugs down the bathroom. Examine your neighborhood drug keep and clinics for choose-again destinations. You may also Look at the DEA Web page for destinations. Here's the link on the FDA Risk-free disposal of medicines Web site: